Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which cognitive deficits gradually worsen with age. The AD symptoms can be divided into three stages: early- (mild), mid- (moderate), and late- (severe) stages. Personality changes could be a sign at the early-stage AD, including depression, apathetic and withdrawn statuses; anxious, irritable and agitated mood; repetitive behaviors, easily angered while facing frustrations, and withdrawals from social and mental challenges. Therefore, we will examine whether personality changes, including such as emotional and social abnormalities would be an early alert in the AD progression.