Ph.D.

　Pharmaceutical Science

1973/10-1976/9

The University of Tokyo

M.S.

　Pharmaceutical Science

1971/10-1973/9

The University of Tokyo

B.S

　Department of Pharmacy

1965/09-1969/6

Taipei Medical College

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Professor, Department of Pharmacology, Cheng Kung University ( 1983/10-presen )

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Chair Professor of National Cheng Kung University ( 2001-present )

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National Chair Professor, Ministy of Education ( 1999-2002 )

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General Director, Department of Life Sciences, National Science Council ( 1999/11-2001/07 )

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Associate Dean, College of Medical, Cheng Kung University ( 1998/09-1999/07 )

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Chairman, Institute of Basic Medical Sciences, Cheng Kung University ( 1994/10-1999/10 )

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Chairman, Department of Pharmacology, Cheng Kung University ( 1983/10-1990/07 )

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Visiting Research Fellow, University of Kentucky, USA ( 1981/09-1983/09 )

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Visiting Scientist, Tokyo Metropolitan Institutes of Gerontology, Japan ( 1979/01-1981/08 )

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Visiting Fellow, National Institute on Aging, NIH, USA ( 1976/10-1978/12 )

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Science Academy Award, Ministry of Education ( 1998 )

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Distinguished Scientist, specially contracted with National Science Council ( 1997/08-2003/07 )

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Board Award, Chinese Education and Culture Foundation ( 1996 )

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Lin, C.H., Yeh, S.H., Leu, T.H., Chang, W.C., Wang, S.T. and Gean, P.W.: Identification of calcineurin as a key signal in the extinction of fear memory. J. Neurosci. 23: 1574-1579, 2003.

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Liu, Y.W., Tseng, H.P., Chen, L.C., Chen, B.K. and Chang, W.C.: Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein β and δ in lipopolysaccharide-induced gene activation of IL -10 in mouse macrophages. J. Immunol. 171: 821-828, 2003 .

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Chen, C.J., Huang, H.S. and Chang, W.C.: Depletion of phospholipid hydroperoxide glutathione peroxidase up-regulates arachidonate metabolism by 12( S )-lipoxygenase and cyclooxygenase 1 human epidermoid carcinoma A431 cells. FASEB J. 17: 1694-1696, 2003

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Chang, W.C.: Cell signaling and gene regulation of human 12( S )-lipoxygenase expression (Invited Review Article). Prost. Other Lipid Mediat. 71: 277-285, 2003.

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Chang, W.C.: Identification of an endogenouse inhibitor of arachidonate metabolism in human epidermoid carcinoma A431 cells (Invited Review Article). J. Biomed. Sci. 203: 599-606, 2003

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Wang, Y.N. and Chang, W.C.: Induction of the disease-associated keratin 16 gene expression by epidermal growth factor is regulated through cooperation of transcription factors Sp1 and c-Jun. J. Biol. Chem. 278: 45848-45857, 2003.

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Chen, LC, Chen, BK, Chang, JM, Chang, WC.: Essential role of c-Jun induction and coactivator p 300 in epidermal growth factor-induced gene expression of cyclooxygenase -2 in human epidermoid carcinoma A431 cells. Biochim. Biophys. Acta 1683: 38-48, 2004.

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Huang, J.H., Su, I.J., Lei, H.Y., Wang, H.C., Lin, W.C., Chang, W.T., Huang, W., Chang, W.C., Chang, Y.S., Chen, C.C. and Lai, M.D.: Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kB and pp 38 mitogen-activated protein kinase. J. Biol.Chem. 279; 46384-46392, 2004

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Lin, C.F., Chen, C.L., Chang, W.T., Jan, M.S., Hsu, L.J., Wu, R.H., Tang, M.J., Chang, W.C. and Lin, Y.S.: Sequential caspase-2 and caspase-8 activation upstream of mitochondria during ceramide- and etoposide-induced apoptosis. J. Biol. Chem. 279: 40755-40761, 2004.

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Wu, M.H., Wang , C.A. , Lin, C.C., Cheng, L.C., Chang, W.C. and Tsai, S.J.: Distinct regulation of cyclooxygenase-2 by interleukin-1β in normal and endometriotic stromal cells. J. Clin. Endoc. Metab. 90: 286-295, 2005

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Lin, C.F., Chen, C.L., Chang, W.T., Jan, M.S., Hsu, L.J., Wu, R.H., Fang, Y.T., Tang, M.J., Chang, W.C. and Lin, Y.S.: Bcl-2 rescues ceramide- and etoposide-induced mitochondrial apoptosis through blockage of caspase-2 activation. J. Biol. Chem. 280: 23758-23765, 2005

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Chen, L.C., Chen, B.K. and Chang, W.C.: Activating protein 1-mediated cyclooxygenase-2 expression is independent of N-terminal phosphorylation of c-Jun. Mol. Pharmacol. 67: 2057-2069, 2005.

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Wang, J.M., Tseng, J.T. and Chang, W.C.: Induction of human NF-IL6 β by epidermal growth factor is mediated through p38 signaling pathway and CREB activation in A431 cells. Mol. Biol. Cell 16: 3365-3376, 2005

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Tzeng, S.J., Chang, W.C. and Huang, J.D.: Transcriptional regulation of the rat Mrp3 gene promoter by the specificity protein (Sp) family members and CCAAT/enhancer binding proteins. J. Biomed. Sci. in press, 2005

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Chang, W.C. and Chen B.K.: Transcription factor Sp1 functional as an anchor protein in gene transcription of human 12( S )-lipoxygenase (Invited Review Article). Biochem. Biophys. Res. Commun. in press, 2005

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Hung, J.J., Wu, C.Y., Liao, P.C. and Chang, W.C.: Hsp90α recruited by Sp1 is important for transcription of 12( S )-lipoxygenase in A431 cells. J. Biol. Chem. 280: 36283-36292, 2005

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Wang, Y.N., Chen, Y.J. and Chang, W.C.: Activation of ERK signaling by epidermal growth factor mediates c-Jun activation and p300 recruitment it keratin 16 gene expression. Mol. Pharmacol . 69: 1-14, 2006.

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Hung, J.J., Wang, Y.T. and Chang W.C.: Sp1 deacetylation induced by phorbol ester recruits p300 to activate the 12( S )- lipoxygenase transcription. Mol. Cell. Biol. 26: 1770-1785, 2006.

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Liu, Y.W., Chen C.C., Tseng H.P. and Chang, W.C.: Lipopolysaccharide -induced transcriptional activation of interleukin-10 is mediated by MAPK- and NF- κ B- induced CCAAT/Enhancer-binding protein δ in mouse macrophages. Cell. Signal. 18: 1492-1500, 2006.

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Wang, J.M., Ko , C.Y., Chen, L.C., Wang, W.L. and Chang, W.C.: Functional role of NF-IL6 β and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene. Nucl . Acids Res. 34: 217-231, 2006.

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Chiang, B.T., Liu, Y.W., Chen, B.K., Wang, J.M. and Chang, W.C.: Direct interaction of C/EBPδ and Sp1 at the GC-enriched promoter region synergizes the IL-10 gene transcription in mouse macrophage. J. Biomed. Sci. 13: 621-635, 2006.

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Huang, H.S., Liu, Z.M., Ding, L., Chang, W.C., Hsu, P.Y., Wang, S.H., Chi, C.C. and Chuang, C.H.: Opposite effect of ERK1/2 and JNK on p53-independent p21 WAF1/CIP1 activation involved in the arsenic trioxide-induced human epidermoid carcinoma A431 cellular cytotoxicity. J. Biomed. Sci. 13: 113-125, 2006.

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Lu, T.J., Lai, W.Y., Huang, C.Y.F., Hsieh, W.J., Yu, J.S., Hsieh, Y.J., Chang, W.T., Leu, T.H., Chang, W.C., Chuang, W.J., Tang, M.J., Chen, T.Y., Lu, T.L. and Lai, M.D.: Inhibition of cell migration by autophophorylated mammalian sterile 20-like kinase (MST3) involves paxillin and protein-tyrosine phosphatase-PEST. J. Biol. Chem. 281: 38405-38417, 2006

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Lin, C.C., Tu, C.F., Yen, M.C., Chen, M.C., Hsieh, W.J., Chang, W.C., Chang, W.T. and Lai, M.T.: Inhibitor of heat shock protein 90 enhances the anti-tumor effect of DNA vaccine targeting clients of heat shock protein. Mol. Ther. 15: 404-410, 2007.

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Chen , B.K., Huang, C.C., Chang, W.C., Chen, Y.J., Kikkawa, U., Ken-ichi Nakahama, K. I., Morita, I. and Chang, W.C.: PP2B-Mediated dephosphorylation of c-Jun C-terminus regulates phorbol ester-induced c-Jun/Sp1 interaction in A431 cells. Mol. Biol. Cell. 18: 1118-1127, 2007.

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Huang, Y.C., Chang, W.C., Su, J.G.J., Cai, J.L., Chen, C.C., Hung, J.J. and Liu, Y.W. Peptidoglycan enhances transcriptional expression of CCAAT/enhancer-binding protein δ gene in mouse macrophages. J. Biomed. Sci. 14: 407-418, 2007.

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Chen, Y.J., Wang, Y.N. and Chang, W.C. ERK2-mediated C-terminal serine phosphorylation of p300 is vital to the regulation of EGF-induced keratin 16 gene expression. J. Biol. Chem. 282: 27215-27228, 2007.

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Wei J., Yan W., Li X., Chang, W.C. and Tai, H.H. Activation of thromboxane receptor α induces expression of cyclooxygenase-2 through multiple signalling pathways in A549 human lung adenocarcinoma cells. Biochem. Pharmacol. 74: 787-800, 2007.

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Lee, P.T., Lio, P.C., Chang, W.C. and Tseng, J.C. EGF increases the interaction between nucleolin and heterogeneous nuclear ribonucleoprotein K/poly(C) binding protein 1 complex to regulate the gastrin mRNA turnover. Mol. Biol. Cell in press, 2007.

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Huang, C.C., Wang, J.M., Kikkawa, U., Mukai, H., Shen M.R., Chen, B.K. and Chang, W.C. Calcineurin-mediated dephosphorylation of c-Jun Ser-243 is required for c-Jun protein stability and cell transformation. Oncogene in press, 2007.

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Liu, Y.W., Chen, C.C., Wang, J.M., Chang, W.C., Huang, Y.C., Chung, S.Y., Chen, B.K. and Hung, J.J. Role of transcriptional factors Sp1, c-Rel, and c-Jun in LPS-induced C/EBP δ gene expression of mouse macrophages. Cell. Mol. Life Sci. in press, 2007.

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Tsou, J.H., Chang, K.Y., Wang, W.C., Tseng, J.T., Su, W.C., Hung, L.Y., Chang, W.C. and Chen, B.K. Nucleolin regulates c-Jun/Sp1-dependent transcriptional activation of cPLA 2 in phorbol ester-treated non-small cell lung cancer A549 cells. Nucleic Acids Research. in press, 2007.