1989

　B.S. School of Pharmacy, College of Medicine, National 　Taiwan University

1993

　Ph.D. Institute of Pharmacology, College of Medicine, National 　Taiwan University

1994

　Joined Cheng Kung University faculty

1997-1998

　Visiting Scholar Department of Biology, University of California 　at San Diego, USA

2001

　Visiting Scholar Department of Neurophysiology, University of 　Tokyo, Faculty of Medicine, Tokyo, Japan

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　Activity-dependent long-lasting changes in the efficacy of synaptic transmission play an important role in the development of neural circuits and are thought to mediate many forms of learning and memory formation processes. The elucidation of the molecular mechanisms by which these changes occur will have profound implications for understanding many important nervous system functions including how future behavior is modified by past environmental experience. Past work from my laboratory has demonstrated that there are a variety of related but mechanistically distinct forms of synaptic plasticity. A major goal of my laboratory is to elucidate both the specific molecular events that are responsible for the triggering of these various forms of synaptic plasticity and the exact modifications in synaptic proteins that are responsible for the observed, long-lasting changes of synaptic efficacy. To accomplish this, we use a combination of electrophysiological and molecular techniques to investigate synaptic plasticity in a variety of different in vitro preparations including thin slices of various regions of the rodent brain and primary culture neurons. Much of the current work in the laboratory is focused on how stress affects the induction of long-term synaptic plasticity in the hippocampus.

　A related area of research in my laboratory is the elucidation of the synaptic modulation of drugs of abuse such as cocaine. Toward this end, we have developed in vitro slice preparations of the medial prefrontal cortex, brain region which is thought to mediate several of the behavioral effects of drugs of abuse. We are currently using a variety of electrophysiological and biochemical techniques with the hope of determining how acute and chronic exposure to drugs of abuse modifies synaptic and circuit function in this brain area. The long-term alteration of synaptic plasticity may have a role in modulation of neural circuitry that underlies the development of cocaine sensitization and addiction.

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Electrophysiology (including extracellular, intracellular and whole-cell patch-clamp recordings), Brain slices, Tissue slice culture, Microscopy, Immunohistochemistry, Immunoblotting assay, Molecular Biology.

1. Lin YT, Chen CC, Huang CC, Nishimori K, Hus KS.* (2017) Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons. Nat. Commun. 8:537.

2. Lin YT, Hsieh TY, Tsai TC, Chen CC, Huang CC, Hsu KS.* (2018) Conditional deletion of hippocampal CA2/CA3a oxytocin receptor impairs the persistence of long-term social recognition memory in mice. J. Neurosci. 38(5):1218-1231.

3. Yang CY, Yu TH, Wen WL, Lin P, Hus KS.* (2019) Conditional deletion of CC2D1A reduces hippocampal synaptic plasticity and impairs cognitive function through Rac1 hyperactivation. J. Neurosci. 39(25):4959-4975.

4. Huang WY, Liu KH, Lin SK, Chen TY, Chen HY, Tseng CY, Chen YP, Wu HM, Hsu KS.* (2020) NADPH oxidase 2 as a potential therapeutic target for protection against cognitive deficits following systemic inflammation in mice. Brain Behav Immun. 84:242-252.

5. Lee IC, Yu TS, Liu WH, Hsu KS.* (2021) Social transmission and buffering of stress-induced hippocampal metaplasticity in mice. J. Neurosci. 41(6):1317-1330.

6. Yang CY, Hung YC, Cheng KH, Ling P, Hsu KS.* (2021) Loss of CC2D1A in glutamatergic neurons results in autistic-like features in mice. Neurotherapeutics 18(3):2021-2039.

7. TsaiTC, Yu TH, Hung YC, Fong LI, Hsu KS.* (2022) Distinct contribution of granular and agranular divisions of the retrosplenial cortex to remote contextual fear memory retrieval. J. Neurosci. 42(5):877-893.

8. Huang WY, Lai YL, Liu KH, Lin SK, Chen HY, Liang CH, Wu HM, Hsu KS.* (2022) TNFa-mediated necroptosis in brain endothelial cells as a potential mechanism of increased seizure susceptibility in mice following systemic inflammation. J. Neuroinflamm. 19(1):29.

9. Yu TH, Wu YJ, Chien ME, Hsu KS.* (2023) Multisession anodal transcranial direct current stimulation enhances adult hippocampal neurogenesis and context discrimination in mice. J. Neurosci. 43(4):635-646.

10. Chen CH, Tsai TC, Wu YJ, Hsu KS.* (2023) Gastric vagal afferent signaling to the basolateral amygdala mediates anxiety-like behaviors in mice with experimental colitis. JCI Insight 8(12):e161874.

11. Huang YC, Wu YJ, Chien ME, Lin YT, Tsai CF, Hsu KS.* (2023) Loss of oxytocin receptors in hilar mossy cells impairs social discrimination. Neurobiol Dis. 187:106311.

12. Cheng KH, Hung YC, Ling P, Hus KS.* (2024) Oxytocin rescues irritability-like behavior in CC2D1A conditional knockout mice. Neuropsychopharmacology 49: 1792-1802.

13. Chang HT, Cheng KH, Hung YC, Hsu KS.* (2025) Oxytocin signaling in the ventral tegmental area mediates social isolation-induced craving for social interaction. J Biomed Sci. 32:37.

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Research NCKU ! (Open Link)