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To study the molecular pathological mechanisms in human metabolic diseases (Insulin resistance, diabetes and its complications etc.).

The main research: (1) Functional roles of A to I RNA editing in metabolic disease; (2) Functional roles of Rab37 in beta-cell function; (3) insulin resistance and beta-cell defects; (4) The association between Islet amyloid polypeptide and  beta-cell defects

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metabolic disease

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molecular biology

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Signal transduction

1. Jui-Ho Wang, Yun-Wen Chen, Shuchen Hsieh, Mei-Lang Kung (2025, Aug). Nanosized Ginger-Derived Phenolic Zingerone Obstructs Cell Cycle G2/M Progression and Initiates Apoptosis in Human Colorectal Cancer. Environmental Toxicology, 40(8):1059-1071.

2. Kai-Pi Cheng, Hsin-Hao Chao, Chin-Ju Hsu, Sheng-Feng Tsai, Yen-Ju Chiu, Yu-Min Kuo, Yun-Wen Chen* (2025, Jul). Reduction of Dietary Fat Rescues High-Fat Diet-Induced Depressive Phenotypes and the Associated Hippocampal Astrocytic Deficits in Mice. Metabolites, 15(7):485. The professor is the corresponding author.

3. Li-Wen Chu, Jun-Yih Chen, Yun-Wen Chen, Shuchen Hsieh, Mei-Lang Kung (2024, Sep). Phytoconstituent-derived zingerone nanoparticles disrupt the cell adhesion mechanism and suppress cell motility in melanoma B16F10 cells. The Journal of Biotechnology, 10:392:48-58.

4. Ta Ngoc Ly, Le My Lan, Ming-Yu Tsai, Yun-Wen Chen, Hsin-Yi Hung (2024, Sep). Comprehensive Exploration of Bromophenol Derivatives: Promising Antibacterial Agents against SA and MRSA. ACS Omega, 9(39):40897-40906.

5. Mei-Lang Kung, Tai-Hua Yang, Chia-Chi Lin, Jia-Yun Ho, Tzu-Chi Hung, Chih-Hsiang Chang, Kuan-Wen Huang, Chien-Chin Chen, Yun-Wen Chen* (2024, Jun). ADAR2 deficiency ameliorates non-alcoholic fatty liver disease and muscle atrophy through modulating serum amyloid A1. Journal of Cachexia, Sarcopenia and Muscle, 15(3):949-962. The professor is the corresponding author.

6. Mei-Lang Kung, Siao Muk Cheng, Yun-Han Wang, Kai-Pi Cheng, Yu-Lin Li, Yi-Tsen Hsiao, Bertrand Chin-Ming Tan, Yun-Wen Chen* (2024, May). Deficiency of ADAR2 ameliorates metabolic-associated fatty liver disease via AMPK signaling pathways in obese mice. Communications Biology, 7(1):594. The professor is the corresponding author.

7. Pin-Han Lin, Chang-Shun Tsai, Chia-Chien Hsu, I-Ren Lee, Yu-Xin Shen, HsiuFang Fan, Yun-Wen Chen*, Ling-Hsien Tu, Wei-Min Liu (2023, May). An environmentally sensitive molecular rotor as a NIR fluorescent probe for the detection of islet amyloid polypeptide. Talanta, 254:124130. The professor is the corresponding author.

8. Sheng-Feng Tsai, Pei-Ling Hsu, Yun-Wen Chen, Mohammad Shahadat Hossain, Pei-Chun Chen, Shun-Fen Tzeng, Po-See Chen, Yu-Min Kuo (2022, Nov). High- fat diet induces depression-like phenotype via astrocyte-mediated hyperactivation of ventral hippocampal glutamatergic afferents to the nucleus accumbens. Molecular Psychiatry.

9. Ke-Yun Xie, Shao-Ju Chien, Bertrand Chin-Ming, Yun-Wen Chen* (2021, Oct). RNA editing of 5-HT2CR impairs insulin secretion of pancreatic beta cells via altered store-operated calcium entry. FASEB Journal. The professor is the corresponding author.

10. Yen-Ju Chiu, Ho-Hsiang Tu, Mei-Lang Kung, Hung-Ju Wu, Yun-Wen Chen* (2021, Sep). Fluoxetine ameliorates high-fat diet-induced metabolic abnormalities partially via reduced adipose triglyceride lipase-mediated adipocyte lipolysis. Biomedicine & Pharmacotherapy, 141:111848. The professor is the corresponding author.

11. Ying-Yiu Lam, Sheng-Feng Tsai, Pei-Chun Chen, Yu-Min Kuo, Yun-Wen Chen* (2021, Aug). Pioglitazone rescues high-fat diet-induced depression-like phenotypes and hippocampal astrocytic deficits in mice. Biomedicine & pharmacotherapy, 140:111734. The professor is the corresponding author.

12. Hao-Kuang Wang, Chih-Yuan Huang, Yun-Wen Chen, Yuan-Ting Sun (2021, Jan). Hyperglycemia compromises the ischemia-provoked dedifferentiation of cerebral pericytes through p21-SOX2 signaling in high-fat diet-induced murine model. Diabetes and Vascular Disease Research, 18(1):1479164121990641.

13. Sy-Ying Leu, Li-Hua Kuo, Wen-Tsan Weng, I-Chia Lien, Ching-Chun Yang, Tai-Tzu Hsieh, Yi-Ning Cheng, Po-Hsiu Chien, Li-Chun Ho, Shun-Hua Chen, Yan-Shen Shan, Yun-Wen Chen, Pei-Jane Tsai, Junne-Ming Sung, Yau-Sheng Tsai (2021, Jan). Host CDK-1 and formin mediate microvillar effacement induced by enterohemorrhagic Escherichia coli. nature communications, 12(1):90.

14. Sy-Ying Leu, Li-Hua Kuo, Wen-Tsan Weng, I-Chia Lien, Ching-Chun Yang, TaiTzu Hsieh, Yi-Ning Cheng, Po-Hsiu Chien, Li-Chun Ho, Shun-Hua Chen, YanShen Shan, Yun-Wen Chen, Pei-Jane Tsai, Junne-Ming Sung, Yau-Sheng Tsai (2020, May). Loss of EGR-1 uncouples compensatory responses of pancreatic β cells. Theranostics, 10(9):4233-4249.

15. Wei-Ling Chen, Shih-Ting Ma, Yun-Wen Chen, Yen-Cheng Chao, Ai-Ci Chan, Ling-Hsien Tu, Wei-Min Liu (2020, Apr). A Fluorogenic Molecule for Probing Islet Amyloid Using Flavonoid as a Scaffold Design. Biochemistry, 59(15):1482- 1492.

16. An-Chi Lin, Hao-Chang Hung, Yun-Wen Chen, Kai-Pi Cheng, Chung-Hao Li, Ching-Han Lin, Chih-Jen Chang, Hung-Tsung Wu, Horng-Yih Ou (2019, Oct). Elevated hedgehog-interacting protein levels in subjects with prediabetes and type 2 diabetes. Journal of Clinical Medicine, 8(10):1635.

17. Wen-Chih Lin, Chih-Yuan Huang, Lin-Fu Lee, Yun-Wen Chen, Chung-Han Ho, Yuan-Ting Sun (2019, Oct). Initial National Institute of Health Stroke Scale to Early Predict the Improvement of Swallowing in Patients with Acute Ischemic Stroke. Journal of Stroke and Cerebrovascular Diseases, 28(10):104297.

18. Yi-Hsuan Hsu, Yun-Wen Chen, Meng-Hsin Wu, Ling-Hsien Tu (2019, June). Protein Glycation by Glyoxal Promotes Amyloid Formation by Islet Amyloid Polypeptide, Biophysical Journal, 116(12):2304-2313.

Research NCKU！（Open Link）