Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University

Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which cognitive deficits gradually worsen with age. The AD symptoms can be divided into three stages: early- (mild), mid- (moderate), and late- (severe) stages. Personality changes could be a sign at the early-stage AD, including depression, apathetic and withdrawn statuses; anxious, irritable and agitated mood; repetitive behaviors, easily angered while facing frustrations, and withdrawals from social and mental challenges. Therefore, we will examine whether personality changes, including such as emotional and social abnormalities would be an early alert in the AD progression.

1. Wang CC, Sung SF, Chang CH, Wang HC, Su YH, Chang WH, Hsiao YH* (2026/03). Systemic inflammation and dorsolateral striatal activity converge to drive repetitive and compulsive-like behaviors caused by chronic stress. Brain, Behavior, and Immunity 135:106525 doi.org/10.1016/j.bbi.2026.106525.

2. Chang CH, Sung SF, Chen CS, Sung KC, Wang HC, Hsiao YH* (2025/07). Lateral septum activation as a central hub for reversing chronic stress-induced novelty-avoidance. Progress in Neuro-Psychopharmacology and Biological Psychiatry 140:111436.

3. Chu CH, Su CH, Hsiao YH, Yu CC, Liao YC, Mao PC, Chen JS, Sun HS* (2024/11). Overexpression of TIAM2S, a critical regulator for the hippocampal-medial prefrontal cortex network, progresses age-related spatial memory impairment. The Journals of Gerontology: Series A 79(11):glae191.

4. Sung KC, Wang LY, Wang CC, Chu CH, Sun HS, Hsiao YH* (2024/10). Enhanced hippocampal TIAM2S expression alleviates cognitive deficits in Alzheimer's disease model mice. Pharmacological Reports 76(5):1032-1043.

5. Lin YF, Chen CA, Hsu FY, Hsiao YH* (2023/03). Elevated hippocampal CRMP5 mediates chronic stress-induced cognitive deficits by disrupting synaptic plasticity, hindering AMPAR trafficking, and triggering cytokine release. International Journal of Molecular Sciences 24(5):4898.

6. Liao WC, Huang CW, Hsiao YH, Sung PS, Fu TF, Chang AYW, Chang HH* (2021/08). Association between the serum coenzyme Q10 level and seizure control in patients with drug-resistant epilepsy. Healthcare 9(9):1118.

7. Lin YF^#, Chen KC^#, Yang YK, Hsiao YH* (2021/07). Collapsin response mediator protein 5 (CRMP5) modulates susceptibility to chronic social defeat stress in mice. Molecular Neurobiology 58(7):3175-3186.

8. Lin YF, Wang LY, Chen CS, Li CC, Hsiao YH* (2021/05). Cellular senescence as a driver of cognitive decline triggered by chronic unpredictable stress. Neurobiology of Stress 15:100341.

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