magnetic resonance imaging
biomedical image analysis

Our lab focuses on MR neuroimaging techniques such as functional MRI, diffusion MRI, MR spectroscopy, and other novel contrast mechanisms. We employ these approaches on preclinical research as well as clinical topic. Current research fields include: 1) fiber tracts in developing brain, 2) MR neuroimaging on small animal model, and 3) brain microstructure in dementia.

- 2024  IFMBE Young Investigator Competition - Third Place, ICBHI 2024
- 2021  Summa Cum Laude Merit Award, ISMRM 2021 Annual Meeting and Exhibition
- 2012  President’s Scholarship, NTHU

1. Hsieh, Y. L.^#, Huang, S. M.^#, Yu, S., Chao, T. N., Chiang, C. W., Kan, Y. Y, Chang, Y. S., Kuo, L. W.*, and Yu, H. S.* Chronic blue light exposure induced spatial anxiety in an adolescent mouse model: Per2 upregulation and altered brain resting-state functional activity. NeuroImage, 2025. (Accepted). doi: 10.1016/j.neuroimage.2025.121259 (^#Equal contribution)

2. Huang, S. M., Hsu, Y. H., Yang, J. J., Lin, C. Y., Tu, M. C.*, Kuo, L. W. Functional and microstructural neurosubstrates between apathy and depressive symptoms in dementia. NeuroImage: Clinical, 2025. 46: 103781. doi: 10.1016/j.nicl.2025.103781

3. Huang, S. M., Cho, K. H., Chang, K., Huang, P. H.*, and Kuo, L. W.* (2024) Altered thalamocortical tract trajectory growth with undisrupted thalamic parcellation pattern in human lissencephaly brain at mid-gestational stage. Neurobiology of Disease, p. 106577. doi: 10.1016/j.nbd.2024.106577

4. Huang, S. M.^#, Ong, C. T.^#, Huang, Y. C.*, Chen, N. H., Leung T. K., Shen, C. Y., Kuo, L. W.* (2024) Resting-State Network Analysis Reveals Altered Functional Brain Connectivity in Essential Tremor. Brain Connectivity, doi: 1089/brain.2024.0004 (^#Equal contribution)

5. Huang, S. M.^#, Wu C. Y.^#, Lin Y. H., Hsieh, H. H., Yang H. C., Chiu, S. C., Peng, S. L.* (2022) Differences in brain activity between normal and diabetic rats under isoflurane anesthesia: A resting-state functional MRI study. BMC Medical Imaging, 22:136. doi: 10.1186/s12880-022-00867-6 (^#Equal contribution)

6. Altunkaya, S.^#, Huang, S. M.^#, Hsu, Y. H., Yang, J. J., Lin C. Y., Kuo, L. W., Tu, M. C.* (2022) Dissociable Functional Brain Networks Associated with Apathy in Subcortical Ischemic Vascular Disease and Alzheimer’s Disease. Frontiers in Aging Neuroscience, 13:717037. doi: 10.3389/fnagi.2021.717037 (^#Equal contribution)

MRI Lab Website(Open Link)