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Latest Research

Decreased plasma gelsolin fosters a fibrotic tumor microenvironment and promotes chemoradiotherapy resistance in esophageal squamous cell carcinoma

Decreased plasma gelsolin fosters a fibrotic tumor microenvironment and promotes chemoradiotherapy resistance in esophageal squamous cell carcinoma
Author：Chih-Hsiung Hsieh, Pei-Shiuan Ho, Wen-Lun Wang, Fu-Hsuan Shih, Chen-Tai Hong, Pei-Wen Wang, Dar-Bin Shieh, Wei-Lun Chang & Yi-Ching Wang
Date：2024/09
Source：Journal of Biomedical Science (2024) 31:90

Dysregulation of SOX17/NRF2 axis confers chemoradiotherapy resistance and emerges as a novel therapeutic target in esophageal squamous cell carcinoma

Dysregulation of SOX17/NRF2 axis confers chemoradiotherapy resistance and emerges as a novel therapeutic target in esophageal squamous cell carcinoma
Author：Chih-Hsiung Hsieh, Wen-Hui Kuan, Wei-Lun Chang, I-Ying Kuo, Hsun Liu, Dar-Bin Shieh, Hsuan Liu, Bertrand Tan & Yi-Ching Wang
Date：2022/10
Source：Journal of Biomedical Science volume 29, Article number: 90 (2022)

The double-edged sword effect of HDAC6 in Aβ toxicities.

The double-edged sword effect of HDAC6 in Aβ toxicities.
Author：Cheng KC, Hwang YL, Chiang HC.
Date：2022/01
Source：FASEB J. 2022 Jan;36(1):e22072. doi: 10.1096/fj.202101061R.

Early Aβ42 Exposure Causes Learning Impairment in Later Life.

Early Aβ42 Exposure Causes Learning Impairment in Later Life.
Author：Cheng KC, Cheung CHA, Chiang HC.
Date：2022/06
Source：Aging Dis. 2022 Jun 1;13(3):868-883

Disrupted cellular calcium homeostasis is responsible for Aβ-induced learning and memory damage and lifespan shortening in a model of Aβ transgenic fly.

Disrupted cellular calcium homeostasis is responsible for Aβ-induced learning and memory damage and lifespan shortening in a model of Aβ transgenic fly.
Author：Cheng KC, Huang CY, Hsieh TC, Chiang HC.
Date：2022/08
Source：IUBMB Life. 2022 Aug;74(8):754-762.

Development of a cancer cells self‑activating and miR‑125a‑5p expressing poly‑pharmacological nanodrug for cancer treatment

Development of a cancer cells self‑activating and miR‑125a‑5p expressing poly‑pharmacological nanodrug for cancer treatment
Author：Chang YC, Shieh MC, Chang YH, Huang WL, Su WC, Cheng FY, Cheung CHA.
Date：2022/08
Source：Int J Mol Med. 2022 Aug;50(2):102.

A dorsal CA2 to ventral CA1 circuit contributes to oxytocinergic modulation of long-term social recognition memory

A dorsal CA2 to ventral CA1 circuit contributes to oxytocinergic modulation of long-term social recognition memory
Author：Tsai TC, Fang YS, Hung YC, Hung LC, Hsu KS.
Date：2022/07
Source：J Biomed Sci. 2022 Jul 10;29(1):50

Distinct Contribution of Granular and Agranular Subdivisions of the Retrosplenial Cortex to Remote Contextual Fear Memory Retrieval

Distinct Contribution of Granular and Agranular Subdivisions of the Retrosplenial Cortex to Remote Contextual Fear Memory Retrieval
Author：Tsai TC, Yu TH, Hung YC, Fong LI, Hsu KS.
Date：2022/02
Source：J Neurosci . 2022 Feb 2;42(5):877-893

TNFα-mediated necroptosis in brain endothelial cells as a potential mechanism of increased seizure susceptibility in mice following systemic inflammation

TNFα-mediated necroptosis in brain endothelial cells as a potential mechanism of increased seizure susceptibility in mice following systemic inflammation
Author：Huang WY, Lai YL, Liu KH, Lin S, Chen HY, Liang CH, Wu HM, Hsu KS.
Date：2022/02
Source：J Neuroinflammation. 2022; 19: 29.

Discovery of Potential Neuroprotective Agents against Paclitaxel-Induced Peripheral Neuropathy.

Discovery of Potential Neuroprotective Agents against Paclitaxel-Induced Peripheral Neuropathy.
Author：Chen YF, Wu CH, Chen LH, Lee HW, Lee JC, Yeh TK, Chang JY, Chou MC, Wu HL, Lai YP, Song JS, Yeh KC, Chen CT, Lee CJ, Shia KS, Shen MR.
Date：2022/03
Source：J Med Chem. 2022 Mar 24;65(6):4767-4782.

The Value of Artificial Intelligence-Assisted Imaging in Identifying Diagnostic Markers of Sarcopenia in Patients with Cancer.

The Value of Artificial Intelligence-Assisted Imaging in Identifying Diagnostic Markers of Sarcopenia in Patients with Cancer.
Author：Huang YT, Tsai YS, Lin PC, Yeh YM, Hsu YT, Wu PY, Shen MR.
Date：2022/03
Source：Dis Markers. 2022 Mar 29;2022:1819841

Integration of an Intensive Care Unit Visualization Dashboard (i-Dashboard) as a Platform to Facilitate Multidisciplinary Rounds: Cluster-Randomized Controlled Trial.

Integration of an Intensive Care Unit Visualization Dashboard (i-Dashboard) as a Platform to Facilitate Multidisciplinary Rounds: Cluster-Randomized Controlled Trial.
Author：Lai CH, Li KW, Hu FW, Su PF, Hsu IL, Huang MH, Huang YT, Liu PY, Shen MR.
Date：2022/05
Source：J Med Internet Res. 2022 May 13;24(5):e35981.

Cutting-Edge AI Technologies Meet Precision Medicine to Improve Cancer Care

Cutting-Edge AI Technologies Meet Precision Medicine to Improve Cancer Care
Author：Lin PC, Tsai YS, Yeh YM, Shen MR.
Date：2022/08
Source：Biomolecules. 2022 Aug 17;12(8):1133

Targeting protumor factor chitinase-3-like-1 secreted by Rab37 vesicles for cancer immunotherapy

Targeting protumor factor chitinase-3-like-1 secreted by Rab37 vesicles for cancer immunotherapy
Author：Yang PS, Yu MH, Hou YC, Chang CP, Lin SC, Kuo IY, Su PC, Cheng HC, Su WC, Shan YS, Wang YC
Date：2022/01
Source：Theranostics 2022; 12(1):340-361

Recent advances in conventional and unconventional vesicular secretion pathways in the tumor microenvironment

Recent advances in conventional and unconventional vesicular secretion pathways in the tumor microenvironment
Author：I.‑Ying Kuo1,2, Chih‑Hsiung Hsieh1, Wan‑Ting Kuo1,3, Chih‑Peng Chang3,4* and Yi‑Ching Wang
Date：2022/08
Source：J Biomed Sci. 2022 Aug 5;29(1):56.

Dysregulated Kras/YY1/ZNF322A/Shh axis trans-criptional enhances neo-angiogenesis to promote lung cancer progression

Dysregulated Kras/YY1/ZNF322A/Shh axis trans-criptional enhances neo-angiogenesis to promote lung cancer progression
Author：Che-Chung Lin, I-Ying Kuo, Li-Ting Wu, Wen-Hui Kuan, Sheng-You Liao, Jayu Jen, You-En Yang, Cheng-Wei Tang, Yi-Rong Chen, Yi-Ching Wang
Date：2020/08
Source：Theranostics 2020, Vol. 10, Issue 22

Inhibition of Sonic Hedgehog Signaling Suppresses Glioma Stem-Like Cells Likely Through Inducing Autophagic Cell Death

Inhibition of Sonic Hedgehog Signaling Suppresses Glioma Stem-Like Cells Likely Through Inducing Autophagic Cell Death
Author：Hung HC, Liu CC, Chuang JY, Su CL, Gean PW.
Date：2020/07
Source：Front Oncol. 2020 Jul 24;10:1233. doi: 10.3389/fonc.2020.01233. eCollection 2020.

Exposure to Novelty Promotes Long-Term Contextual Fear Memory Formation in Juvenile Mice: Evidence for a Behavioral Tagging

Exposure to Novelty Promotes Long-Term Contextual Fear Memory Formation in Juvenile Mice: Evidence for a Behavioral Tagging
Author：Chen N, Tsai TC, Hsu KS.
Date：2020/09
Source：Mol Neurobiol. 2020 Sep;57(9):3956-3968. doi: 10.1007/s12035-020-02005-1.

Author Correction: Germline susceptibility variants impact clinical outcome and therapeutic strategies for stage III colorectal cancer

Author Correction: Germline susceptibility variants impact clinical outcome and therapeutic strategies for stage III colorectal cancer
Author：Lin PC, Yeh YM, Wu PY, Hsu KF, Chang JY, Shen MR.
Date：2020/07
Source：Sci Rep. 2020 Jul 17;10(1):12216. doi: 10.1038/s41598-020-69145-1.

Oleic acid-induced NOX4 is dependent on ANGPTL4 expression to promote human colorectal cancer metastasis

Oleic acid-induced NOX4 is dependent on ANGPTL4 expression to promote human colorectal cancer metastasis
Author：Shen CJ, Chang KY, Lin BW, Lin WT, Su CM, Tsai JP, Liao YH, Hung LY, Chang WC, Chen BK.
Date：2020/05
Source：Theranostics.10(16):7083-7099.
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