國立成功大學醫學院藥理學研究所

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Deubiquitinase USP24 activated by IL-6/STAT3 enhances PD-1 protein stability and suppresses T cell antitumor response

作者：Hung-Chia Hsieh, Ming-Jer Young,Kuan-Yu Chen, Wu-Chou Su, Chien-Chung Lin, Yi-Ting Yen,Jan-Jong Hung and Yi-Ching Wang

出版年月：2025/04

出處：Science Advances 16 Apr 2025 Vol 11, Issue 16 DOI: 10.1126/sciadv.adt4258

Decreased plasma gelsolin fosters a fibrotic tumor microenvironment and promotes chemoradiotherapy resistance in esophageal squamous cell carcinoma

作者：Chih-Hsiung Hsieh, Pei-Shiuan Ho, Wen-Lun Wang, Fu-Hsuan Shih, Chen-Tai Hong, Pei-Wen Wang, Dar-Bin Shieh, Wei-Lun Chang & Yi-Ching Wang

出版年月：2024/09

出處：Journal of Biomedical Science

ADAR2 deficiency ameliorates non-alcoholic fatty liver disease and muscle atrophy through modulating serum amyloid A1

作者：Mei-Lang Kung, Tai-Hua Yang, Chia-Chi Lin, Jia-Yun Ho, Tzu-Chi Hung, Chih-Hsiang Chang, Kuan-Wen Huang, Chien-Chin Chen, Yun-Wen Chen*

出版年月：2024/06

出處：J Cachexia Sarcopenia Muscle . 2024 Jun;15(3):949-962.

Deficiency of ADAR2 ameliorates metabolic-associated fatty liver disease via AMPK signaling pathways in obese mice

作者：Mei-Lang Kung, Siao Muk Cheng, Yun-Han Wang, Kai-Pi Cheng, Yu-Lin Li, Yi-Tsen Hsiao, Bertrand Chin-Ming Tan & Yun-Wen Chen*

出版年月：2024/05

出處：Commun Biol . 2024 May 17;7(1):594

Rab37 mediates trafficking and membrane presentation of PD-1 to sustain T cell exhaustion in lung cancer.

作者：Kuo WT, Kuo IY, Hsieh HC, Wu ST, Su WC, Wang YC

出版年月：2024/02

出處：J Biomed Sci. 2024 Feb 7;31(1):20.doi: 10.1186/s12929-024-01009-6.PMID: 38321486

Downregulation of microRNA 326 enhances ZNF322A expression transcrip activity and tumorigenic effects in lung cancer

作者：Shih-Hsuan Huang,Hung-Chia Hsieh,Jiunn-Min Shieh,Wou-Chou Su,Yi-Ching Wang

出版年月：2023/08

出處：BioFactors. 2023;1–14.

UBE1C is upregulated and promotes neddylation of p53 in lung cancer

作者：Liu H, Shih YH, Wang WL, Chang WL, Wang YC.

出版年月：2023/10

出處：FASEB J. 2023 Oct;37(10):e23181. doi: 10.1096/fj.202300629R.

Dysregulation of SOX17/NRF2 axis confers chemoradiotherapy resistance and emerges as a novel therapeutic target in esophageal squamous cell carcinoma

作者：Chih-Hsiung Hsieh, Wen-Hui Kuan, Wei-Lun Chang, I-Ying Kuo, Hsun Liu, Dar-Bin Shieh, Hsuan Liu, Bertrand Tan & Yi-Ching Wang

出版年月：2022/10

出處：Journal of Biomedical Science volume 29, Article number: 90 (2022)

Development of a cancer cells self‑activating and miR‑125a‑5p expressing poly‑pharmacological nanodrug for cancer treatment.

作者：Chang YC, Shieh MC, Chang YH, Huang WL, Su WC, Cheng FY, Cheung CHA.

出版年月：2022/08

出處：Int J Mol Med. 2022 Aug;50(2):102.

The double-edged sword effect of HDAC6 in Aβ toxicities.

作者：Cheng KC, Hwang YL, Chiang HC.

出版年月：2022/01

出處：FASEB J. 2022 Jan;36(1):e22072. doi: 10.1096/fj.202101061R.

Early Aβ42 Exposure Causes Learning Impairment in Later Life

作者：Cheng KC, Cheung CHA, Chiang HC.

出版年月：2022/06

出處：Aging Dis. 2022 Jun 1;13(3):868-883. doi: 10.14336/AD.2021.1015. eCollection 2022 Jun.

Disrupted cellular calcium homeostasis is responsible for Aβ-induced learning and memory damage and lifespan shortening in a model of Aβ transgenic fly

作者：Cheng KC, Huang CY, Hsieh TC, Chiang HC.

出版年月：2022/08

出處：IUBMB Life. 2022 Aug;74(8):754-762. doi: 10.1002/iub.2621.

A dorsal CA2 to ventral CA1 circuit contributes to oxytocinergic modulation of long-term social recognition memory

作者：Tsai TC, Fang YS, Hung YC, Hung LC, Hsu KS.

出版年月：2022/07

出處：J Biomed Sci .

Distinct Contribution of Granular and Agranular Subdivisions of the Retrosplenial Cortex to Remote Contextual Fear Memory Retrieval

作者：Tsai TC, Yu TH, Hung YC, Fong LI, Hsu KS.

出版年月：2022/02

出處：J Neurosci. 2022 Feb 2;42(5):877-893.

TNFα-mediated necroptosis in brain endothelial cells as a potential mechanism of increased seizure susceptibility in mice following systemic inflammation

作者：Huang WY, Lai YL, Liu KH, Lin S, Chen HY, Liang CH, Wu HM, Hsu KS.

出版年月：2022/02

出處：J Neuroinflammation. 2022 Feb 2;19(1):29.

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